berserk -
To behave in a wild and uncontrolled way as a result of something unexpected happening.
When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.
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deranged -
Behaving in an uncontrolled or dangerous way because of mental illness
Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs
noun
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crackpot -
A slightly strange or foolish person
Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.
adjective
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kooky -
Strange and different, in a funny way
Salvador Dali's kooky appearance was only exceeded by his even more bizarre paintings.
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batty -
Mad and slightly crazy, usually in a humorous way
The computer system wouldn't let Greg log on or change his password, and it was driving him batty.
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lunatic -
A person who is crazy
Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.
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unhinged -
Mentally unbalanced and unstable
Trevor crossed the street when he saw the unhinged person yelling at him.
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loony -
Crazy or silly
The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.
adjective
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zany -
Amusingly unconventional and different
Einstein was unique among geniuses in that he also had a silly and zany side of his personality.
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daffy -
Silly, different, strange, and funny
Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.
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nuts -
Crazy, insane, or stupid, often in a humorous way
Bill's friends thought he was nuts for swimming in the middle of the winter.
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hysterical -
Having uncontrolled extreme emotion
When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.