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cantankerous - Bad-tempered, argumentative, and uncooperative

The constant arguing of the cantankerous couple living above Ann always kept her up at night.

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crank - Someone who others think has unusual ideas or behaves strangely

Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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megalomaniac - Someone who has an unnaturally strong wish for power and control.

The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.

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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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wacky - Something that is strange and different to the point of amusement.

George’s grandmother was well known and loved for her wacky taste in shoes.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

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psycho - A person with severe mental health issues, often describing someone who behaves in an erratic or dangerous manner.

She accused him of being a psycho and told him to leave after he repeatedly showed up uninvited and acted innappropriately.

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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

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delusional - Seeing or believing things that are not real

Betty was confident that she would be a millionaire by the time she would be 25, but her friends thought she was delusional.

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zany - Amusingly unconventional and different

Einstein was unique among geniuses in that he also had a silly and zany side of his personality.