bonkers -
Mentally unbalanced, mad and crazy, usually meant humorously
There were many long stretches of time that Joan was cooped up in the house with her kids, and it was making her go bonkers.
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daffy -
Silly, different, strange, and funny
Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.
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mischievous -
Playfully causing trouble or annoyance, often in a fun or harmless way.
Her mischievous cat knocked over the plant just to get her attention.
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zany -
Amusingly unconventional and different
Einstein was unique among geniuses in that he also had a silly and zany side of his personality.
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mercurial -
Changing emotions suddenly and often
Fred loved almost everything about his wife except her mercurial behavior, where her moods changed suddenly between sadness and happiness, or love and anger
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catatonic -
Appearing to be in a daze or stupor; unresponsive, not moving or reacting.
His experiment with psychodelics left him in a catatonic state where he showed almost no emotion, and it that took years for him to recover.
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blabbermouth -
An overly talkative person who speaks without thinking.
Don't tell Jerry things you don't want others to know about, because you can’t trust a blabbermouth with secrets.
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unhinged -
Mentally unbalanced and unstable
Trevor crossed the street when he saw the unhinged person yelling at him.
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hysterical -
Having uncontrolled extreme emotion
When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.
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loony -
Crazy or silly
The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.
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kooky -
Strange and different, in a funny way
Salvador Dali's kooky appearance was only exceeded by his even more bizarre paintings.
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compulsion -
A strong, irresistible urge to do something, often against one's better judgement.
His gambling problem stemmed from a deep psychological compulsion.