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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

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unhinged - Mentally unbalanced and unstable

Trevor crossed the street when he saw the unhinged person yelling at him.

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psycho - A person with severe mental health issues, often describing someone who behaves in an erratic or dangerous manner.

She accused him of being a psycho and told him to leave after he repeatedly showed up uninvited and acted innappropriately.

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lunacy - Stupid or crazy ideas or behavior that is likely to have bad results

When Edwin Hubble suggested in 1922 that most of the little dots in the sky are entire galaxies, most scientists thought that the idea was sheer lunacy.

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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deranged - Behaving in an uncontrolled or dangerous way because of mental illness

Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

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catatonic - Appearing to be in a daze or stupor; unresponsive, not moving or reacting.

His experiment with psychodelics left him in a catatonic state where he showed almost no emotion, and it that took years for him to recover.

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delirious - In a disturbed state of mind, often due to illness or fever, leading to confusion and hallucinations.

After three sleepless nights, he was delirious and barely able to speak clearly.

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wacky - Something that is strange and different to the point of amusement.

George’s grandmother was well known and loved for her wacky taste in shoes.

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crank - Someone who others think has unusual ideas or behaves strangely

Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.

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zany - Amusingly unconventional and different

Einstein was unique among geniuses in that he also had a silly and zany side of his personality.