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verb

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degenerate - To decline or deteriorate physically, mentally, or morally

After Bill started taking drugs, his life went downhill until his his relationships, health, and finances had totally degenerated.

verb

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wince - To give a slight involuntary grimace or shrinking movement of the body out of or in anticipation of pain or distress

Tiger winced as he realized he had hit the ball too far beyond the hole.

noun

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affliction - Something that causes pain or suffering.

When Pharoah didn't let the people go, Moses gave Egypt one affliction after another.

noun

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standstill - A halt in activity, usually temporary but total.

Traffic came to a standstill after the accident on the highway.

noun

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angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.

adjective

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grueling - Extremely tiring and demanding

Troops go through grueling training before they can finally serve their country.

adjective

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strenuous - Requiring great effort, energy, or strength, needing vigorous or intense in activity or action.

Hiking up the mountain was a strenuous task, but the view was worth it.

noun

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throes - Intense or violent pain and struggle, especially accompanying birth, death, or great change

Samantha experienced agonizing pain during the throes of childbirth.

adjective

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humiliated - To feel ashamed after someone embarrasses you in front of others.

When Jim revealed to everyone at the party that Marty hadn't even finished 6th grade, Marty felt humiliated.

adjective

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excruciating - Intensely painful

Becky had to see the dentist because her toothache was causing her excruciating pain.

noun

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ordeal - A painful or horrific experience, especially a protracted one

Knowing it was a fight to the death, the gladiator realized that this was an ordeal he would have to overcome if he wanted to survive.

adjective

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tragic - Something very sad often involving suffering.

The story of how Oedipus mistakenly killed his father and married his mother is a tragic story.