throes -
Intense or violent pain and struggle, especially accompanying birth, death, or great change
Samantha experienced agonizing pain during the throes of childbirth.
adjective
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exasperating -
Intensely irritating; infuriating
Molly tried to enter the information in the online form, but she found the confusing directions so exasperating that she grabbed her own hair and screamed in frustration.
verb
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torment -
Cause to experience severe mental or physical suffering
William enjoyed tormenting his younger sister until she would run away and complain to their mother.
adjective
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agonizing -
Something that causes great physical or mental pain.
After she took the final exam, it was agonizing to her that for a whole week she wouldn't find out the results.
verb
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writhe -
To make continual twisting, squirming movements or contortions of the body
The soccer player writhed in pain on the ground after spraining his ankle.
adjective
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tragic -
Something very sad often involving suffering.
The story of how Oedipus mistakenly killed his father and married his mother is a tragic story.
verb
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wince -
To give a slight involuntary grimace or shrinking movement of the body out of or in anticipation of pain or distress
Tiger winced as he realized he had hit the ball too far beyond the hole.
adjective
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afflicted -
Suffering from a serious problem, illness, or pain, be it mental or physical.
Many people are afflicted with anxiety in high-pressure situations.
noun
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exile -
The state of being banned or forced to live away from one's native country, often for political reasons.
After the revolution, the king lived in exile in a foreign land.
noun
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anguish -
Severe mental or physical pain or suffering
With her personal and professional life in disarray, Jenny's anguish was often too much for her to bear.
noun
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cramps -
A painful, involuntary contraction of muscles
When Sharon got cramps in her stomach after eating the fish, she suspected that it may have been spoiled.
noun
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pang -
A sudden sharp pain or painful emotion
The year was 1900, and Dmitri felt a pang of nostalgia and regret as he boarded the boat for America, knowing that he would probably never see his 'old world' again.