verb
See noun
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plague - To cause constant worry, annoyance, or distress, often by repeatedly confronting someone with problems or challenges.
adjective
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tragic - Something very sad often involving suffering.
noun
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anguish - Severe mental or physical pain or suffering
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wince - To give a slight involuntary grimace or shrinking movement of the body out of or in anticipation of pain or distress
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writhe - To make continual twisting, squirming movements or contortions of the body
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hardship - Severe suffering or difficulty caused by lack of necessities like food, money, or shelter.
See verb
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burden - something you carry or withstand with much difficulty.