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noun

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shackles - A device, such as a chain or cuff, designed to physically limit or control a person or thing's movement.

Shackles were placed on the prisoner's feet so that he would not be able to run away and escape.

noun

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throes - Intense or violent pain and struggle, especially accompanying birth, death, or great change

Samantha experienced agonizing pain during the throes of childbirth.

verb

See noun

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plague - To cause constant worry, annoyance, or distress, often by repeatedly confronting someone with problems or challenges.

She was plagued by constant headaches, making it hard for her to focus on her work.

noun

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standstill - A halt in activity, usually temporary but total.

Traffic came to a standstill after the accident on the highway.

adjective

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agonizing - Something that causes great physical or mental pain.

After she took the final exam, it was agonizing to her that for a whole week she wouldn't find out the results.

noun

See verb

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burden - something you carry or withstand with much difficulty.

Financial debt can be a huge burden on families.

noun

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cramps - A painful, involuntary contraction of muscles

When Sharon got cramps in her stomach after eating the fish, she suspected that it may have been spoiled.

noun

See verb

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torment - Severe physical or mental suffering

Sufferers of depression must deal with the torment of their own thoughts on a regular basis.

noun

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angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.

adjective

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afflicted - Suffering from a serious problem, illness, or pain, be it mental or physical.

Many people are afflicted with anxiety in high-pressure situations.

noun

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pang - A sudden sharp pain or painful emotion

The year was 1900, and Dmitri felt a pang of nostalgia and regret as he boarded the boat for America, knowing that he would probably never see his 'old world' again.

noun

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agony - Extreme physical or mental suffering

Max was in physical agony as he rode his bicycle up the long mountain trail, but spiritually and emotionally he was in heaven.