batty -
Mad and slightly crazy, usually in a humorous way
The computer system wouldn't let Greg log on or change his password, and it was driving him batty.
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lunacy -
Stupid or crazy ideas or behavior that is likely to have bad results
When Edwin Hubble suggested in 1922 that most of the little dots in the sky are entire galaxies, most scientists thought that the idea was sheer lunacy.
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nuts -
Crazy, insane, or stupid, often in a humorous way
Bill's friends thought he was nuts for swimming in the middle of the winter.
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crackpot -
A slightly strange or foolish person
Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.
adjective
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unhinged -
Mentally unbalanced and unstable
Trevor crossed the street when he saw the unhinged person yelling at him.
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weirdo -
A person whose dress or behavior seems strange
The weirdo kept peeking at everyone from behind the bushes.
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lunatic -
A person who is crazy
Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.
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crank -
Someone who others think has unusual ideas or behaves strangely
Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.
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deranged -
Behaving in an uncontrolled or dangerous way because of mental illness
Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs
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daffy -
Silly, different, strange, and funny
Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.
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zany -
Amusingly unconventional and different
Einstein was unique among geniuses in that he also had a silly and zany side of his personality.
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psycho -
A person with severe mental health issues, often describing someone who behaves in an erratic or dangerous manner.
She accused him of being a psycho and told him to leave after he repeatedly showed up uninvited and acted innappropriately.