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Aggravating - Causing annoyance, irritation, and frustraton by repeated annoying behavior.

It’s so aggravating when people talk loudly during a movie.

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bristle - (of hair or fur) stand upright away from the skin, especially in anger or fear

In the darkness lit by only the moon, Warren's hair bristled at the creepy sounds around him.

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Bumpy - Unstable or rough, especially describing a ride or journey.

The bike ride was bumpy because of all the potholes.

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Burden - To place a load or responsibility on someone.

Please don’t burden yourself with more work than you can handle.

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chafe - To be annoyed or lose patience because of rules or limits

Though Ted loved his father (and boss), he chafed under his father's strict supervision, and he was looking forward to the day when his father would retire so he could run the company himself.

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sweltering - Uncomfortably hot

In India during the summer, the sweltering heat literally melted the roads.

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squeamish - (of a person) easily made to feel sick, faint, or disgusted, especially by unpleasant images, such as the sight of blood

Nico was so squeamish about receiving a flu shot that he broke out into a sweat.

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harried - To be busy and annoyed by the demands of others

Jim didn't like being a waiter, because he always felt harried by the demands of all the customers.

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Hangover - A set of unpleasant physical effects following heavy alcohol consumption, such as headache, nausea, and fatigue.

He spent the whole morning in bed, recovering from a bad hangover after a night of drinking.

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stuffy - (of a place) lacking fresh air or ventilation

The office was so stuffy that multiple fans had to be running at all times.

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skittish - (of an animal, especially of a horse) excitable or easily scared

Bill's horse was especially skittish around people it didn't know, so they had to be careful when Bill's friend Fred wanted to stroke the horse's mane.

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fidget - Make small movements, especially of the hands and feet, through nervousness or impatience

Ron nervously fidgeted with his hands before giving the speech to 10,000 people.