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writhe - To make continual twisting, squirming movements or contortions of the body

The soccer player writhed in pain on the ground after spraining his ankle.

verb

See noun

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torment - Cause to experience severe mental or physical suffering

William enjoyed tormenting his younger sister until she would run away and complain to their mother.

noun

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anguish - Severe mental or physical pain or suffering

With her personal and professional life in disarray, Jenny's anguish was often too much for her to bear.

noun

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angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.

verb

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degenerate - To decline or deteriorate physically, mentally, or morally

After Bill started taking drugs, his life went downhill until his his relationships, health, and finances had totally degenerated.

adjective

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afflicted - Suffering from a serious problem, illness, or pain, be it mental or physical.

Many people are afflicted with anxiety in high-pressure situations.

adjective

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exasperating - Intensely irritating; infuriating

Molly tried to enter the information in the online form, but she found the confusing directions so exasperating that she grabbed her own hair and screamed in frustration.

noun

See verb

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torment - Severe physical or mental suffering

Sufferers of depression must deal with the torment of their own thoughts on a regular basis.

verb

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flinch - To make a quick, nervous movement of the face or body as an instinctive reaction to surprise, fear or pain

Debbie was very brave and didn’t flinch when the nurse put the needle in her arm to give her the flu shot.

adjective

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strenuous - Requiring great effort, energy, or strength, needing vigorous or intense in activity or action.

Hiking up the mountain was a strenuous task, but the view was worth it.

noun

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standstill - A halt in activity, usually temporary but total.

Traffic came to a standstill after the accident on the highway.

adjective

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grueling - Extremely tiring and demanding

Troops go through grueling training before they can finally serve their country.