irritate - To make someone angry, or annoyed; or to make apart of your body sore or painful.
After the mother spent hours peparing the Friday night meal, she was irritated when the whole family ate quickly and left without thanking her or even saying anything in appreciation.
astute - Ability to understand things quickly and clearly, and to use the knowledge well
From a very early age, Gail instinctively knew everything about business, and and after college she proved to be an astute business woman, and became a millionaire before the age of 30.